Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 10/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763780 | 0.94 | TP53 (0.42) | TP53MAPTSMN1; SMN2KIF11ABCG2 | |
| SCHEMBL11912413 | 0.90 | TP53 (0.46) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL8404053 | 0.90 | TP53 (0.43) | TP53MAPTSMN1; SMN2KIF11ABCG2 | |
| SCHEMBL11912403 | 0.89 | KIF11 (0.48) | TP53MAPTSMN1; SMN2KIF11ABCG2 | |
| SCHEMBL8404050 | 0.87 | TP53 (0.43) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL763841 | 0.87 | TP53 (0.45) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL8404052 | 0.85 | TP53 (0.42) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL764736 | 0.85 | LMNA (0.44) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL763995 | 0.85 | TP53 (0.42) | TP53MAPTSMN1; SMN2KIF11ABCG2 | |
| SCHEMBL8404058 | 0.84 | KIF11 (0.43) | TP53MAPTSMN1; SMN2KIF11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |