Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 20/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 16/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16350075 | 0.84 | OPRD1 (0.78) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| SCHEMBL16300058 | 0.84 | OPRD1 (0.55) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| SCHEMBL2071422 | 0.83 | OPRD1 (0.75) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| SCHEMBL10259045 | 0.83 | OPRD1 (1.00) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL2073195 | 0.82 | OPRD1 (0.74) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| SCHEMBL467302 | 0.81 | OPRD1 (1.00) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL2071898 | 0.80 | OPRD1 (0.98) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| SCHEMBL10258339 | 0.80 | OPRD1 (1.00) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| SCHEMBL471421 | 0.79 | OPRD1 (0.87) | OPRD1CYP2D6KCNH2OPRM1OPRK1 | |
| SCHEMBL471448 | 0.78 | OPRD1 (1.00) | OPRD1CYP2D6KCNH2OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165356-A1 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165356-A1 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | OPRK1, OPRD1, OPRL1 | OPRD1 2/4885CYP2D6 138/4885KCNH2 1285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.