Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SCN1A | P35498 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73562 | 0.86 | HRH3 (0.72) | HRH3PDE1APDE1BPDE1CKCNH2 | |
| SCHEMBL737990 | 0.85 | HRH3 (0.75) | HRH3PDE1APDE1BPDE1CKCNH2 | |
| SCHEMBL2819407 | 0.85 | HRH3 (0.75) | HRH3PDE1APDE1BPDE1CKCNH2 | |
| SCHEMBL8360712 | 0.85 | RAB9A (0.68) | RAB9ANPC1ALDH1A1USP2HPGD | |
| SCHEMBL1776344 | 0.84 | MEN1 (0.55) | RAB9ANPC1ALDH1A1USP2HPGD | |
| SCHEMBL10817906 | 0.83 | RAB9A (0.76) | RAB9ANPC1ALDH1A1USP2HPGD | |
| SCHEMBL7945866 | 0.83 | RAB9A (0.66) | RAB9ANPC1ALDH1A1USP2HPGD | |
| SCHEMBL12359053 | 0.83 | USP2 (0.91) | RAB9ANPC1ALDH1A1USP2HPGD | |
| SCHEMBL76269 | 0.83 | RAB9A (0.66) | RAB9ANPC1ALDH1A1USP2HPGD | |
| SCHEMBL19091219 | 0.83 | RAB9A (0.79) | RAB9ANPC1ALDH1A1USP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732543-B1 | TETRACYCLIC CARBOLINE DERATIVES FOR INHIBITING ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2017-05-10 | — | — | EP | disclosed |
| EP-2431369-A2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC Therapeutics, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |