Sugi Predict

Sugi Predict / Compounds / SCHEMBL16303448

SCHEMBL16303448

SCHEMBL16303448

Nc1n[nH]c2cccc(-n3cc(NC(=O)Nc4ccccc4)cn3)c12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 19/20 0.59
▸ KIT P10721 13/20 0.59
▸ FLT3 P36888 13/20 0.59
▸ LCK P06239 3/20 0.59
▸ CSF1R P07333 3/20 0.59
▸ FLT1 P17948 3/20 0.59
▸ FLT4 P35916 3/20 0.59
▸ PLK4 O00444 2/20 0.59
▸ AURKA O14965 2/20 0.59
▸ ROCK2 O75116 2/20 0.59
▸ INSR P06213 2/20 0.59
▸ LYN P07948 2/20 0.59
▸ MET P08581 2/20 0.59
▸ FGFR1 P11362 2/20 0.59
▸ SRC P12931 2/20 0.59
▸ PRKACA P17612 2/20 0.59
▸ RPS6KB1 P23443 2/20 0.59
▸ MARK3 P27448 2/20 0.59
▸ CSNK1D P48730 2/20 0.59
▸ GSK3B P49841 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16559768 0.89 KDR (0.47) KDRKITFLT3LCKCSF1R
SCHEMBL16559769 0.83 KDR (0.53) KDRKITFLT3LCKCSF1R
SCHEMBL16303633 0.82 KDR (0.65) KDRKITFLT3LCKCSF1R
SCHEMBL18559619 0.81 KDR (0.51) KDRKITFLT3LCKCSF1R
SCHEMBL18559622 0.79 KDR (0.38) KDRKITFLT3LCKCSF1R
SCHEMBL545988 0.75 KDR (0.70) KDRKITFLT3LCKCSF1R
SCHEMBL421644 0.75 KDR (1.00) KDRKITFLT3LCKCSF1R
SCHEMBL16456826 0.73 KDR (0.66) KDRKITFLT3LCKCSF1R
SCHEMBL19846879 0.72 ABL1 (0.41) KDRKITFLT3LCKCSF1R
SCHEMBL23719148 0.71 MAPK10 (0.59) KDRFGFR1CLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11352343-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2022-06-07 — — US disclosed
US-20200299272-A1 Urea Derivatives and Uses Thereof KALA BIO, Inc. 2020-09-24 — — US disclosed
US-10723719-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2020-07-28 — — US disclosed
US-20190284172-A1 Urea Derivatives and Uses Thereof KALA BIO, Inc. 2019-09-19 — — US disclosed
US-10329280-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2019-06-25 — — US disclosed
US-10316022-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2019-06-11 — — US disclosed
US-20180037573-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2018-02-08 — — US disclosed
US-20180037573-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2018-02-08 — — US disclosed
US-20180037572-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2018-02-08 — — US disclosed
US-20180037572-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2018-02-08 — — US disclosed
US-9802922-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2017-10-31 — — US disclosed
US-9802922-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2017-10-31 — — US disclosed
US-20170129876-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2017-05-11 — — US disclosed
US-20170129876-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2017-05-11 — — US disclosed
US-9580421-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2017-02-28 — — US disclosed
US-9580421-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2017-02-28 — — US disclosed
US-20160060264-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2016-03-03 — — US disclosed
US-9212145-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2015-12-15 — — US disclosed
US-20150072986-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2015-03-12 — — US disclosed
WO-2014201127-A2 UREA DERIVATIVES AND USES THEREOF KALA PHARMACEUTICALS, INC. (US) 2014-12-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150072986-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-10316022-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-11352343-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-20180037572-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-10723719-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-20180037573-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-20200299272-A1 Urea Derivatives and Uses Thereof UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-10329280-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-20190284172-A1 Urea Derivatives and Uses Thereof UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-20170129876-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885
US-20160060264-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885KIT 51/4885FLT3 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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