Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.53 |
| ▸ | KIT | P10721 | 13/20 | 0.53 |
| ▸ | FLT3 | P36888 | 12/20 | 0.53 |
| ▸ | CSF1R | P07333 | 9/20 | 0.53 |
| ▸ | FLT1 | P17948 | 9/20 | 0.53 |
| ▸ | FLT4 | P35916 | 9/20 | 0.53 |
| ▸ | LYN | P07948 | 8/20 | 0.53 |
| ▸ | SRC | P12931 | 8/20 | 0.53 |
| ▸ | BLK | P51451 | 8/20 | 0.53 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | FES | P07332 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16303633 | 0.91 | KDR (0.65) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL18559619 | 0.89 | KDR (0.51) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL16303448 | 0.83 | KDR (0.59) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL16559768 | 0.83 | KDR (0.47) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL18559622 | 0.73 | KDR (0.38) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL16303695 | 0.70 | KDR (0.78) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL422415 | 0.70 | KDR (0.79) | KDRKITFLT3CSF1RFLT1 | |
| Linifanib SCHEMBL29375368 | 0.69 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| Linifanib SCHEMBL93804 | 0.69 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL25779641 | 0.69 | KDR (0.70) | KDRKITFLT3CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2018-02-08 | — | — | US | disclosed |
| US-20180037572-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2018-02-08 | — | — | US | disclosed |
| US-9802922-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-20170129876-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2017-05-11 | — | — | US | disclosed |
| US-9580421-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160060264-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2016-03-03 | — | — | US | disclosed |
| US-9212145-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-20150072986-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2015-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072986-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885KIT 51/4885FLT3 62/4885 |
| US-20180037572-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885KIT 51/4885FLT3 62/4885 |
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885KIT 51/4885FLT3 62/4885 |
| US-20170129876-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885KIT 51/4885FLT3 62/4885 |
| US-20160060264-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885KIT 51/4885FLT3 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.