Sugi Predict

Sugi Predict / Compounds / SCHEMBL16303676

SCHEMBL16303676

SCHEMBL16303676

Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c3ccccc23)c1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 20/20 0.80
▸ PDGFRB P09619 5/20 0.80
▸ FLT3 P36888 11/20 0.77
▸ CSF1R P07333 9/20 0.77
▸ FLT4 P35916 9/20 0.77
▸ KIT P10721 9/20 0.77
▸ LYN P07948 8/20 0.77
▸ FLT1 P17948 8/20 0.77
▸ SRC P12931 7/20 0.77
▸ BLK P51451 7/20 0.77
▸ LCK P06239 7/20 0.77
▸ FYN P06241 5/20 0.77
▸ PLK4 O00444 3/20 0.72
▸ AURKA O14965 3/20 0.72
▸ ROCK2 O75116 3/20 0.72
▸ CDK1 P06493 3/20 0.72
▸ MET P08581 3/20 0.72
▸ PRKACA P17612 3/20 0.72
▸ RPS6KB1 P23443 3/20 0.72
▸ CSNK1D P48730 3/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3469407 0.90 KDR (0.79) KDRPDGFRBFLT3CSF1RFLT4
Water SCHEMBL15808658 0.89 KDR (0.78) KDRPDGFRBFLT3CSF1RFLT4
SCHEMBL29918230 0.89 KDR (1.00) KDRPDGFRBFLT3CSF1RFLT4
SCHEMBL17929413 0.89 KDR (1.00) KDRPDGFRBFLT3CSF1RFLT4
SCHEMBL420765 0.87 KDR (1.00) KDRPDGFRBFLT3CSF1RFLT4
SCHEMBL27931429 0.86 KDR (0.70) KDRPDGFRBFLT3CSF1RFLT4
SCHEMBL421934 0.86 KDR (0.82) KDRPDGFRBFLT3CSF1RFLT4
SCHEMBL423705 0.84 KDR (0.80) KDRPDGFRBFLT3CSF1RFLT4
Linifanib SCHEMBL29375368 0.84 KDR (1.00) KDRPDGFRBFLT3CSF1RFLT4
Linifanib SCHEMBL93804 0.84 KDR (1.00) KDRPDGFRBFLT3CSF1RFLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11352343-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2022-06-07 — — US disclosed
US-20200299272-A1 Urea Derivatives and Uses Thereof KALA BIO, Inc. 2020-09-24 — — US disclosed
US-10723719-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2020-07-28 — — US disclosed
US-20190284172-A1 Urea Derivatives and Uses Thereof KALA BIO, Inc. 2019-09-19 — — US disclosed
US-10329280-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2019-06-25 — — US disclosed
US-10316022-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2019-06-11 — — US disclosed
US-20180037573-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2018-02-08 — — US disclosed
US-20180037572-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2018-02-08 — — US disclosed
US-9802922-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2017-10-31 — — US disclosed
US-20170129876-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2017-05-11 — — US disclosed
US-9580421-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2017-02-28 — — US disclosed
US-20160060264-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2016-03-03 — — US disclosed
US-9212145-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2015-12-15 — — US disclosed
US-20150072986-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2015-03-12 — — US disclosed
WO-2014201127-A2 UREA DERIVATIVES AND USES THEREOF KALA PHARMACEUTICALS, INC. (US) 2014-12-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150072986-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-10316022-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-11352343-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-20180037572-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-10723719-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-20180037573-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-20200299272-A1 Urea Derivatives and Uses Thereof UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-10329280-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-20190284172-A1 Urea Derivatives and Uses Thereof UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-20170129876-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885
US-20160060264-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 KDR 6/4885PDGFRB 1451/4885FLT3 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.