Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.70 |
| ▸ | FLT3 | P36888 | 13/20 | 0.70 |
| ▸ | KIT | P10721 | 11/20 | 0.70 |
| ▸ | CSF1R | P07333 | 10/20 | 0.70 |
| ▸ | FLT4 | P35916 | 10/20 | 0.70 |
| ▸ | FLT1 | P17948 | 9/20 | 0.70 |
| ▸ | LYN | P07948 | 8/20 | 0.70 |
| ▸ | SRC | P12931 | 7/20 | 0.70 |
| ▸ | BLK | P51451 | 7/20 | 0.70 |
| ▸ | PLK4 | O00444 | 4/20 | 0.70 |
| ▸ | AURKA | O14965 | 4/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.70 |
| ▸ | MET | P08581 | 4/20 | 0.70 |
| ▸ | PRKACA | P17612 | 4/20 | 0.70 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.70 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.70 |
| ▸ | STK3 | Q13188 | 4/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.70 |
| ▸ | MARK2 | Q7KZI7 | 4/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16303698 | 0.86 | KDR (0.69) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL16303687 | 0.86 | KDR (0.68) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL16303696 | 0.86 | KDR (0.68) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL422603 | 0.85 | KDR (0.78) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL3469407 | 0.85 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL16303694 | 0.85 | KDR (0.77) | KDRFLT3KITCSF1RFLT4 | |
| Water SCHEMBL15808658 | 0.84 | KDR (0.78) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL29375368 | 0.82 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL93804 | 0.82 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL424019 | 0.82 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352343-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20200299272-A1 | Urea Derivatives and Uses Thereof | KALA BIO, Inc. | 2020-09-24 | — | — | US | disclosed |
| US-10723719-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190284172-A1 | Urea Derivatives and Uses Thereof | KALA BIO, Inc. | 2019-09-19 | — | — | US | disclosed |
| US-10329280-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2019-06-25 | — | — | US | disclosed |
| US-10316022-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2018-02-08 | — | — | US | disclosed |
| US-20180037572-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2018-02-08 | — | — | US | disclosed |
| US-9802922-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-20170129876-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2017-05-11 | — | — | US | disclosed |
| US-9580421-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160060264-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2016-03-03 | — | — | US | disclosed |
| US-9212145-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-20150072986-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2015-03-12 | — | — | US | disclosed |
| WO-2014201127-A2 | UREA DERIVATIVES AND USES THEREOF | KALA PHARMACEUTICALS, INC. (US) | 2014-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072986-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-10316022-B2 | Urea derivatives and uses thereof | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-11352343-B2 | Urea derivatives and uses thereof | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-20180037572-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-10723719-B2 | Urea derivatives and uses thereof | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-20200299272-A1 | Urea Derivatives and Uses Thereof | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-10329280-B2 | Urea derivatives and uses thereof | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-20190284172-A1 | Urea Derivatives and Uses Thereof | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-20170129876-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
| US-20160060264-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | KDR 6/4885FLT3 62/4885KIT 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.