Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.55 |
| ▸ | NOS3 | P29474 | 2/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29384557 | 1.00 | MAPK10 (0.55) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| Hydrochloric Acid SCHEMBL27495714 | 0.98 | MAPK10 (0.54) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| SCHEMBL5348300 | 0.89 | NOS3 (0.58) | MAPK10NOS3NOS2MAOAGABRA1 | |
| SCHEMBL28542282 | 0.85 | MAPK10 (0.50) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| SCHEMBL29498358 | 0.85 | MAPK10 (0.55) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| SCHEMBL13805616 | 0.85 | NOS3 (0.49) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| SCHEMBL11269191 | 0.85 | MAPK10 (0.55) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| SCHEMBL6718892 | 0.85 | NOS3 (0.58) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| SCHEMBL21063722 | 0.85 | CA1 (0.52) | MAPK10NOS3NOS2MAOAALDH1A1 | |
| SCHEMBL30965936 | 0.85 | CA1 (0.52) | MAPK10NOS3NOS2MAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116218804-A | Imine reductase mutant and method for preparing (S) -1-phenyl-1, 2,3, 4-tetrahydroisoquinoline by reduction thereof | 迪嘉药业集团股份有限公司 | 2023-06-06 | — | — | CN | claimed |
| CN-112142663-B | Synthesis method of (S) -1-phenyl-1, 2,3, 4-tetrahydroisoquinoline | 中山奕安泰医药科技有限公司 | 2022-03-22 | — | — | CN | claimed |
| CN-112142663-A | Synthesis method of (S) -1-phenyl-1, 2,3, 4-tetrahydroisoquinoline | 中山奕安泰医药科技有限公司 | 2020-12-29 | — | — | CN | claimed |
| CN-109438348-A | The preparation method and preparation method thereof of one kind (S) -1- phenyl -1,2,3,4- tetrahydroisoquinoline | 凯瑞斯德生化(苏州)有限公司 | 2019-03-08 | — | — | CN | claimed |
| CN-108383785-A | A kind of preparation method and application of Solifenacin derivative | 浙江海洋大学 | 2018-08-10 | — | — | CN | claimed |
| CN-108239029-A | The preparation of tetrahydroisoquinoliderivatives compound and its salt and medical usage | 中国医学科学院药物研究所 | 2018-07-03 | — | — | CN | claimed |
| CN-103159677-B | The preparation method of IQL | Ji'nan Healtang Biotechnology Co., Ltd. (CN) | 2016-03-16 | — | — | CN | claimed |
| CN-103159677-A | 1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline preparation method | JINAN SHENGQUAN HEALTANG BIOLOG TECHNOLOGY CO LTD | 2013-06-19 | — | — | CN | claimed |
| CN-101851200-A | Synthetic method of 1-phenyl-1,2,3,4-tetrahydroisoquinoline | UNIV WUHAN TECH | 2010-10-06 | — | — | CN | claimed |
| JP-7072663-A | — | — | None | — | — | JP | disclosed |
| CN-118146154-A | Method for synergistic catalysis of selective oxidative dehydrogenation of tetrahydroisoquinoline | 西安石油大学 | 2024-06-07 | — | — | CN | disclosed |
| US-20230406843-A1 | Progranulin Modulators and Methods of Using the Same | JANSSEN PHARMACEUTICA NV (BE) | 2023-12-21 | — | — | US | disclosed |
| CN-114195713-B | Method for synthesizing dihydroisoquinoline by catalyzing selective dehydrogenation of tetrahydroisoquinoline | 广东众源药业有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-116997547-A | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2023-11-03 | — | — | CN | disclosed |
| JP-H0772663-A | ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER | CANON INC | 1995-03-17 | — | — | JP | disclosed |
| EP-0336228-B1 | Tetrahydroisoquinolines and tetrahydrobenzazepines and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-09 | — | — | EP | disclosed |
| US-5059608-A | Anticonvulsants, antiischemic agents | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-10-22 | — | — | US | disclosed |
| CN-1036758-A | Bicyclic amine compound and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1989-11-01 | — | — | CN | disclosed |
| EP-0336228-A1 | Tetrahydroisoquinolines and tetrahydrobenzazepines and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-10-11 | — | — | EP | disclosed |
| US-4321382-A | 2-Amino-11b-aryl-benzo[a]quinolizines | RICHARDSON-MERRELL INC. (US) | 1982-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230406843-A1 | Progranulin Modulators and Methods of Using the Same | GRN, PSEN2, PSEN1 | MAPK10 2024/4885NOS3 4240/4885NOS2 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.