Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17092646 | 0.89 | MAPT (0.52) | KDM4EMAPTTHRBHTTHPGDS | |
| SCHEMBL1466005 | 0.86 | MAPT (0.55) | KDM4EMAPTTHRBHTTHPGDS | |
| SCHEMBL1980646 | 0.86 | KDM4E (0.55) | KDM4EMAPTTHRBHTTHPGDS | |
| SCHEMBL3141500 | 0.84 | KDM4E (0.58) | KDM4EMAPTTHRBHTTHPGDS | |
| SCHEMBL12058890 | 0.84 | MAPT (0.53) | KDM4EMAPTTHRBHTTP2RY14 | |
| SCHEMBL17115816 | 0.81 | HPGDS (0.51) | KDM4EMAPTTHRBTOP2AHPGDS | |
| SCHEMBL1980796 | 0.81 | TLR7 (0.53) | KDM4EMAPTTHRBHTTKMT2A | |
| SCHEMBL25114605 | 0.79 | HRH3 (0.47) | KDM4ETHRBKMT2AHPGDHSD17B10 | |
| SCHEMBL25337924 | 0.79 | KDM4E (0.55) | KDM4EMAPTTHRBHTTHPGDS | |
| SCHEMBL15642665 | 0.78 | P2RY14 (0.49) | KDM4EMAPTTHRBHTTP2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009424-B1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-12-20 | — | — | EP | disclosed |
| CN-105308024-B | The nitrogenous heteroaromatic amide compound of two ring types | 安斯泰来制药株式会社 | 2017-10-27 | — | — | CN | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| EP-3009424-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-09-24 | — | — | US | disclosed |
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-09-24 | — | — | US | disclosed |
| WO-2014199933-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2014-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | PIK3CA, SLC16A3, MCTS1 | KDM4E 399/4885MAPT 2753/4885THRB 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.