MCTS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL928309	0.52	13/20
SCHEMBL927411	0.50	13/20
SCHEMBL926958	0.61	12/20
SCHEMBL929883	0.60	12/20
SCHEMBL928596	0.52	12/20
SCHEMBL927777	0.39	12/20
SCHEMBL928717	0.59	11/20
Bindarit (SCHEMBL187885)	0.55	10/20
Bindarit (SCHEMBL371677)	0.54	10/20
SCHEMBL928508	0.48	10/20
SCHEMBL927983	0.53	9/20
SCHEMBL3856473	0.50	8/20
SCHEMBL927364	0.47	8/20
SCHEMBL7056007	0.47	8/20
SCHEMBL927862	0.46	8/20
SCHEMBL3332697	0.52	7/20
SCHEMBL927309	0.48	7/20
SCHEMBL9830073	0.55	6/20
SCHEMBL1650536	0.52	6/20
SCHEMBL6356718	0.52	6/20

Clinical trials — most relevant to MCTS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients	PHASE1/PHASE2	COMPLETED
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia	PHASE2	RECRUITING
A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas	PHASE2	COMPLETED
SB939 in Treating Patients With Recurrent or Metastatic Prostate Cancer	PHASE2	COMPLETED
A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b	PHASE1	COMPLETED
Azacitidine and Abatacept in Relapsed or Refractory T-Cell Lymphoma	PHASE1	SUSPENDED
Application of 68Ga-Pentixafor PET/CT for Thymoma	EARLY_PHASE1	UNKNOWN
Program to Establish the Genetic and Immunologic Profile of Patient's Tumor for All Types of Advanced Cancer	nan	RECRUITING
Biology of Thymic Tumors	nan	COMPLETED
Retrospective Analysis of Patients With Metastatic Renal Cell Carcinoma Treated With CABOzantinib	nan	RECRUITING
AI-Based Fine Morphological Subtyping of Myeloma Single Cells for Predicting FISH Abnormalities	nan	ENROLLING_BY_INVITATION
Biomarkers in Blood and Bone Marrow Samples From Patients With Acute Lymphoblastic Leukemia	nan	COMPLETED
Molecular Genetic Basis of Invasive Breast Cancer Risk Associated With Lobular Carcinoma in Situ	nan	COMPLETED
Gene Expression in Predicting Response to Paclitaxel in Patients With Breast Cancer	nan	UNKNOWN
Urinary Biomarkers in the Detection of Urothelial Carcinoma of the Bladder	nan	COMPLETED
Comparison of the Diagnostic Accuracy: US-guided Percutaneous Lung Biopsies vs CT-guided in Peripheral Lung Lesions	nan	RECRUITING
PRospective Multiple Myeloma Impact Study	nan	ACTIVE_NOT_RECRUITING
Study of Adult T-Cell Leukemia/Lymphoma Among Carriers of HTLV-1	nan	COMPLETED
Biomarkers in Tumor Tissue Samples From Patients With Peripheral T-cell Lymphoma or Natural Killer Cell Neoplasms	nan	COMPLETED
Understanding Immunotherapy Resistance Mechanisms in Advanced Melanoma	nan	COMPLETED
The Etiology and Progression of Brain Tumors	nan	COMPLETED
Studying Biomarkers in Samples From Younger Patients With Wilms Tumor	nan	COMPLETED
A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study	nan	COMPLETED
Cellular and Molecular Biomarkers in Patients With Lichen Planus	nan	RECRUITING
Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations	nan	COMPLETED
Studying Tumor Samples From Young Patients With Neuroblastoma	nan	COMPLETED
Studying DNA and Outcome in Patients With Advanced Colorectal Cancer Treated With Fluorouracil and Oxaliplatin With or Without Bevacizumab on Clinial Trial E-3200	nan	COMPLETED
Genetic Biomarkers in Saliva Samples From Patients With Ewing Sarcoma	nan	COMPLETED
Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate	nan	COMPLETED
Validation of a Clinical Algorithm for the Diagnosis of Recessive Ataxias	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MCTS1 binder may also engage these)

Protein	Name	Similarity
Q9DB27	—	1.000	Q9DB27 →
Q2KIE4	—	1.000	Q2KIE4 →
Q6NRJ7	—	1.000	Q6NRJ7 →
Q5ZI42	—	1.000	Q5ZI42 →
Q7ZV34	—	1.000	Q7ZV34 →
Q4G009	—	1.000	Q4G009 →
Q6DER1	—	1.000	Q6DER1 →
Q5PPY1	—	1.000	Q5PPY1 →
Q9CQ21	—	1.000	Q9CQ21 →
A0A3B3IRV3	—	1.000	A0A3B3IRV3 →
Q9W445	—	0.999	Q9W445 →
P87313	—	0.996	P87313 →
Q86KL4	—	0.992	Q86KL4 →
P89886	—	0.992	P89886 →
Q75AA8	—	0.990	Q75AA8 →
P21894	—	0.972	P21894 →
P09445	—	0.971	P09445 →
EEF2	Elongation factor 2	0.971	landscape →
Q757H7	—	0.971	Q757H7 →
Q6BIJ0	—	0.971	Q6BIJ0 →
P06786	—	0.971	P06786 →
O14179	—	0.970	O14179 →
P55823	—	0.970	P55823 →
P05197	—	0.970	P05197 →
Q5R8Z3	—	0.970	Q5R8Z3 →
P58252	—	0.970	P58252 →
O94609	—	0.969	O94609 →
Q54Y20	—	0.969	Q54Y20 →
P56335	—	0.969	P56335 →
Q9Y7Y8	—	0.968	Q9Y7Y8 →