Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682507 | 0.86 | GRM2 (0.46) | GRM2LMNAALDH1A1TSHRMAPT | |
| SCHEMBL1036013 | 0.77 | GRM2 (0.54) | GRM2LMNAALDH1A1TSHRMAPT | |
| SCHEMBL1039732 | 0.77 | GRM2 (0.54) | GRM2LMNAALDH1A1TSHRMAPT | |
| SCHEMBL171698 | 0.74 | LMNA (0.51) | GRM2LMNAALDH1A1MAPTHCRTR1 | |
| SCHEMBL18185700 | 0.74 | PDE1C (0.51) | GRM2LMNAALDH1A1TSHRMAPT | |
| SCHEMBL2056309 | 0.74 | ALDH1A1 (0.50) | GRM2ALDH1A1TSHRCHRM5ABL1 | |
| SCHEMBL13047939 | 0.73 | LMNA (0.51) | GRM2LMNAMAPTTP53EPHX2 | |
| SCHEMBL169742 | 0.73 | ALDH1A1 (0.44) | GRM2LMNAALDH1A1TSHRCHRM5 | |
| SCHEMBL171738 | 0.73 | ALDH1A1 (0.44) | GRM2LMNAALDH1A1TSHRMAPT | |
| SCHEMBL687245 | 0.72 | GRM2 (0.43) | GRM2LMNAALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045836-B1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-03-05 | — | — | EP | disclosed |