Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.43 |
| ▸ | STIM1 | Q13586 | 6/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 6/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | CD74 | P04233 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182162 | 0.86 | KMO (0.53) | RPA1STIM1ORAI1KMOCD74 | |
| SCHEMBL182038 | 0.85 | RPA1 (0.45) | RPA1STIM1ORAI1KMOCD74 | |
| SCHEMBL2708467 | 0.84 | RPA1 (0.50) | RPA1STIM1ORAI1KMOMAP4K4 | |
| SCHEMBL181876 | 0.84 | KMT2A (0.51) | RPA1STIM1ORAI1KMOCD74 | |
| SCHEMBL181928 | 0.84 | HTT (0.52) | RPA1STIM1ORAI1KMOCD74 | |
| SCHEMBL182136 | 0.84 | KEAP1 (0.51) | RPA1KMOCD74MIFNPC1 | |
| SCHEMBL182299 | 0.83 | AURKA (0.53) | RPA1STIM1ORAI1KMOCD74 | |
| SCHEMBL10194338 | 0.82 | KDM5A (0.53) | RPA1STIM1ORAI1KMOCD74 | |
| SCHEMBL181888 | 0.81 | STIM1 (0.57) | RPA1STIM1ORAI1NPC1RAB9A | |
| SCHEMBL185371 | 0.81 | KMT2A (0.49) | STIM1ORAI1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363129-A1 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases | PTC Therapeutics, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |