Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.39 |
| ▸ | MAP2 | P11137 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | PNLIP | P16233 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319445 | 0.83 | SLC6A2 (0.49) | SCN9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16319965 | 0.81 | SCN9A (0.59) | SCN9A | |
| SCHEMBL365684 | 0.78 | SCN10A (0.47) | SCN9AALPLSLC6A2SLC6A4SCN8A | |
| SCHEMBL31743138 | 0.78 | MAP2 (0.50) | ALPLEPHX2EPAS1MAP2PNLIP | |
| SCHEMBL4638596 | 0.78 | AVPR2 (0.47) | ALPLMAP2PNLIPCNR2 | |
| SCHEMBL16319403 | 0.74 | EPAS1 (0.38) | EPAS1SLC6A2SLC6A4 | |
| SCHEMBL16320077 | 0.73 | SCN9A (0.62) | SCN9A | |
| SCHEMBL15094323 | 0.73 | TTR (0.54) | SLC6A2SLC6A4SLC6A3SCN8ASCN10A | |
| SCHEMBL15094277 | 0.72 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3SCN8ASCN10A | |
| SCHEMBL16319179 | 0.71 | HTT (0.47) | SCN8ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |