Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365692 | 0.96 | LMNA (0.48) | HTTLMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL365684 | 0.82 | SCN10A (0.47) | HTTLMNACYP1A2CYP2C19PARP14 | |
| SCHEMBL16319445 | 0.82 | SLC6A2 (0.49) | HTTLMNAPARP14PARP10CSF1R | |
| SCHEMBL16319558 | 0.82 | SCN9A (0.43) | HTTLMNAPARP14PARP10CSF1R | |
| SCHEMBL16319728 | 0.80 | SCN8A (0.44) | HTTLMNASCN8ASCN10ARAB9A | |
| SCHEMBL28143231 | 0.80 | PARP10 (0.48) | HTTLMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL16319893 | 0.80 | SCN9A (0.58) | SCN8ASCN10A | |
| SCHEMBL30553104 | 0.80 | SCN8A (0.58) | LMNACSF1RSCN8ASCN10A | |
| SCHEMBL16175331 | 0.78 | MKNK1 (0.45) | HTTLMNAPARP14PARP10CSF1R | |
| SCHEMBL15094065 | 0.77 | HTT (0.50) | HTTLMNAPARP14PARP10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |