Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319803 | 0.81 | SLC6A4 (0.44) | SLC22A12ARSLC6A4SLC6A2KCNH2 | |
| SCHEMBL365994 | 0.77 | AR (0.46) | SLC22A12AR | |
| SCHEMBL18189524 | 0.77 | IDH1 (0.50) | SLC22A12ARIDH1SLC6A4SLC6A2 | |
| SCHEMBL16319451 | 0.74 | AR (0.46) | SLC22A12ARKDM4EALDH1A1 | |
| SCHEMBL16319245 | 0.74 | SCN9A (0.44) | EPAS1SLC6A4SLC6A2 | |
| SCHEMBL363575 | 0.73 | AR (0.51) | SLC22A12ARSLC6A4 | |
| SCHEMBL8396955 | 0.73 | EPHX2 (0.50) | EPAS1SLC6A4SLC6A2KCNH2 | |
| SCHEMBL16319665 | 0.71 | ESRRA (0.47) | SLC22A12ARSLC6A4SLC6A2NOS2 | |
| SCHEMBL7931554 | 0.71 | EPAS1 (0.42) | EPAS1SLC6A4KCNH2 | |
| SCHEMBL16319638 | 0.70 | SLC22A12 (0.48) | SLC22A12ARKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |