Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679379 | 0.90 | SCN9A (0.56) | SCN9ASCN5A | |
| SCHEMBL16319304 | 0.88 | SCN9A (0.58) | SCN9ASCN5ASLC22A12 | |
| SCHEMBL680506 | 0.85 | SCN9A (0.63) | SCN9ASCN5AABCB11CYP2C9SCN1A | |
| SCHEMBL16319484 | 0.84 | SCN9A (0.60) | SCN9ASCN5AABCB11CYP2C9SCN1A | |
| SCHEMBL16239728 | 0.83 | SCN9A (0.57) | SCN9ASCN5A | |
| SCHEMBL16319658 | 0.83 | SCN9A (0.58) | SCN9ASCN5AABCB11CYP2C9SCN1A | |
| SCHEMBL16319893 | 0.83 | SCN9A (0.58) | SCN9ASCN5AABCB11CYP2C9SCN1A | |
| SCHEMBL16319547 | 0.83 | SCN9A (0.68) | SCN9ASCN5AABCB11CYP2C9SCN1A | |
| SCHEMBL16175401 | 0.82 | SCN9A (0.53) | SCN9ASCN5AABCB11CYP2C9SCN1A | |
| SCHEMBL16319578 | 0.82 | SCN9A (0.77) | SCN9ASCN5ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |