Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.46 |
| ▸ | SCN2B | O60939 | 1/20 | 0.46 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319536 | 0.96 | SCN9A (0.54) | SCN9ASCN5ASCN8ASCN10ASCN2B | |
| SCHEMBL16319452 | 0.87 | SCN9A (0.66) | SCN9ASCN5ASCN8ASCN1ASCN4A | |
| SCHEMBL16319893 | 0.86 | SCN9A (0.58) | SCN9ASCN5ASCN8ASCN10AABCB11 | |
| SCHEMBL16319340 | 0.85 | SCN9A (0.57) | SCN9ASCN5ASCN8ASCN10AABCB11 | |
| SCHEMBL16319657 | 0.85 | SCN9A (0.58) | SCN9ASCN5ASCN8ASCN10A | |
| SCHEMBL16319754 | 0.84 | SCN9A (0.62) | SCN9ASCN5ASCN8ASCN10AABCB11 | |
| SCHEMBL680139 | 0.84 | SCN9A (0.61) | SCN9ASCN5ASCN8ASCN10AABCB11 | |
| SCHEMBL16319658 | 0.82 | SCN9A (0.58) | SCN9ASCN5ASCN8ASCN10AABCB11 | |
| SCHEMBL16319559 | 0.82 | SCN9A (0.53) | SCN9ASCN5ASCN8ASCN10AABCB11 | |
| SCHEMBL16319313 | 0.81 | SCN9A (0.64) | SCN9ASCN5ASCN2BSCN1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |