Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370151 | 0.89 | TTR (0.43) | TTRPOLBKDM4EALDH1A1MEN1 | |
| SCHEMBL927573 | 0.86 | ALDH1A1 (0.62) | TTRKDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10574721 | 0.85 | ALDH1A1 (0.61) | TTRKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10887493 | 0.85 | ALDH1A1 (0.61) | TTRKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL15094072 | 0.82 | TTR (0.68) | TTRPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL16319923 | 0.81 | FLT1 (0.59) | MAPTSMN1; SMN2FLT1FLT4KDR | |
| SCHEMBL21327408 | 0.81 | SCN8A (0.60) | TTRGRIK1HTT | |
| SCHEMBL11374742 | 0.80 | KDM4E (0.65) | POLBKDM4EMEN1KMT2AHPGD | |
| SCHEMBL11398514 | 0.79 | HTT (0.69) | TTRKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL31335594 | 0.79 | AKR1C3 (0.51) | TTRPOLBKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |