SCHEMBL16319482

SCHEMBL16319482

COc1c(C#N)ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)c1F

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 14/20 0.55
PLA2G7 Q13093 6/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15096357 0.85 AR (0.60) ARPLA2G7
SCHEMBL16319486 0.82 AR (0.61) ARPLA2G7
SCHEMBL24998718 0.79 AR (0.57) ARPLA2G7
SCHEMBL9103229 0.79 AR (0.57) ARPLA2G7
SCHEMBL16319739 0.78 AR (0.78) AR
SCHEMBL876881 0.78 AR (0.60) ARPLA2G7
SCHEMBL28696659 0.78 PLA2G7 (0.67) ARPLA2G7
SCHEMBL875634 0.78 AR (0.60) ARPLA2G7
SCHEMBL28673067 0.78 PLA2G7 (0.67) ARPLA2G7
SCHEMBL16319516 0.77 SCN9A (0.48) PLA2G7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593427-B1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LTD (GB) 2014-12-24 EP disclosed