Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | ERN1 | O75460 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809674 | 0.85 | SCN8A (0.47) | ALDH1A1ERN1HPGDHTR2ASLC6A4 | |
| SCHEMBL16507404 | 0.83 | ALDH1A1 (0.54) | ALDH1A1ERN1TTRLMNACYP1A2 | |
| SCHEMBL19563667 | 0.81 | ALDH1A1 (0.50) | ALDH1A1ERN1HPGDTTRSLC6A4 | |
| SCHEMBL16319704 | 0.81 | ALDH1A1 (0.53) | ALDH1A1ERN1HPGDTTRSLC6A4 | |
| SCHEMBL19563634 | 0.81 | ALDH1A1 (0.64) | ALDH1A1ERN1HPGDTTRSLC6A4 | |
| SCHEMBL18570618 | 0.80 | SCN8A (0.47) | ALDH1A1ERN1HPGDTTRSLC6A4 | |
| SCHEMBL24512757 | 0.79 | TDP1 (0.44) | ALDH1A1ERN1TDP1 | |
| SCHEMBL18570748 | 0.77 | HTR2A (0.43) | ALDH1A1ERN1HPGDHTR2ASLC6A4 | |
| SCHEMBL19563648 | 0.77 | SCN8A (0.47) | ALDH1A1ERN1HPGDTTRHTR2A | |
| SCHEMBL756641 | 0.76 | ALDH1A1 (0.51) | ALDH1A1ERN1LMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |