Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570748 | 0.86 | HTR2A (0.43) | SCN8ASCN10AERN1ALDH1A1HPGD | |
| SCHEMBL19563648 | 0.86 | SCN8A (0.47) | SCN8ASCN10AERN1ALDH1A1HPGD | |
| SCHEMBL16319608 | 0.85 | ALDH1A1 (0.45) | SCN8ASCN10AERN1ALDH1A1HPGD | |
| SCHEMBL22809762 | 0.84 | ERN1 (0.46) | ERN1ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL2419953 | 0.84 | ALDH1A1 (0.61) | ERN1ALDH1A1HPGDLMNACYP1A2 | |
| SCHEMBL19563671 | 0.82 | ERN1 (0.46) | SCN8ASCN10AERN1ALDH1A1LMNA | |
| SCHEMBL19563576 | 0.81 | SCN8A (0.49) | SCN8ASCN10AERN1ALDH1A1LMNA | |
| SCHEMBL19563733 | 0.81 | EPAS1 (0.49) | SCN8ASCN10AERN1ALDH1A1HPGD | |
| SCHEMBL29956352 | 0.80 | ERN1 (0.58) | ERN1ALDH1A1HPGDLMNACYP1A2 | |
| SCHEMBL95806 | 0.80 | ERN1 (0.58) | ERN1ALDH1A1HPGDLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |