Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.52 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.51 |
| ▸ | OXTR | P30559 | 3/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.48 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630075 | 0.92 | NPSR1 (0.52) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL1630069 | 0.92 | KMT2A (0.54) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL1630065 | 0.92 | KMT2A (0.52) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL1629046 | 0.92 | OXTR (0.60) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL1631700 | 0.90 | HTT (0.55) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL3427036 | 0.89 | MAPT (0.52) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL1629236 | 0.88 | CRHBP (0.56) | HTTMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL1629400 | 0.88 | OXTR (0.55) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL1630074 | 0.87 | MAPT (0.49) | KMT2AHTTMAPTNPSR1ALDH1A1 | |
| SCHEMBL1630997 | 0.85 | CRHBP (0.62) | KMT2AHTTMAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932269-B2 | Sulfonamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932269-B2 | Sulfonamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932269-B2 | Sulfonamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090186920-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-23 | — | — | US | disclosed |
| US-20090186920-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-23 | — | — | US | disclosed |
| US-20090186920-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186920-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HCRTR2, HCRTR1, NPSR1 | KMT2A 934/4885HTT 673/4885MAPT 2667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.