SCHEMBL16322751

SCHEMBL16322751

CCC(=O)N[C@H]1CC[C@@H](N(C)C(=O)c2ccc(-c3ccc(F)c(Cl)c3)cc2)C1

nearest known ligand 0.73

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16365811 1.00 FASN (0.73) FASN
SCHEMBL16324318 0.92 FASN (0.75) FASN
SCHEMBL16323833 0.89 FASN (0.80) FASN
SCHEMBL16365760 0.88 FASN (0.77) FASN
SCHEMBL16323182 0.88 FASN (0.77) FASN
SCHEMBL18924345 0.87 FASN (0.76) FASN
SCHEMBL16322938 0.87 FASN (0.73) FASN
SCHEMBL19391154 0.87 FASN (0.73) FASN
SCHEMBL19391149 0.87 FASN (0.73) FASN
SCHEMBL18924524 0.87 FASN (0.77) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3010916-B1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2017-09-27 EP claimed
US-9670142-B2 1,3-diaminocyclopentane carboxamide derivatives MERCK PATENT GMBH (DE) 2017-06-06 US claimed
EP-3010916-A1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES Merck Patent GmbH (DE) 2016-04-27 EP claimed
WO-2014202168-A1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2014-12-24 WO claimed
US-20200222400-A1 METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS JANSSEN PHARMACEUTICA NV (BE) 2020-07-16 US disclosed
EP-3010916-B1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2017-09-27 EP disclosed
EP-3010916-B1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2017-09-27 EP disclosed
US-9670142-B2 1,3-diaminocyclopentane carboxamide derivatives MERCK PATENT GMBH (DE) 2017-06-06 US disclosed
US-9670142-B2 1,3-diaminocyclopentane carboxamide derivatives MERCK PATENT GMBH (DE) 2017-06-06 US disclosed
US-9670142-B2 1,3-diaminocyclopentane carboxamide derivatives MERCK PATENT GMBH (DE) 2017-06-06 US disclosed
US-20160130214-A1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2016-05-12 US disclosed
US-20160130214-A1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2016-05-12 US disclosed
US-20160130214-A1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2016-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200222400-A1 METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS NLN, CLN6, OTC FASN 2790/4885
US-20160130214-A1 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES FASN, FADS1, FADS2 FASN 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.