Eltanexor

Eltanexor

SCHEMBL16324809

NC(=O)/C(=C/n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)c1cncnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XPO1 O14980 14/20 1.00
RANBP1 P43487 1/20 1.00
KCNH2 Q12809 1/20 1.00
ESR1 P03372 1/20 0.48
HTR1A P08908 1/20 0.48
PTGS1 P23219 1/20 0.48
PTGS2 P35354 1/20 0.48
HRH1 P35367 1/20 0.48
PDE4D Q08499 1/20 0.48
SLC29A1 Q99808 1/20 0.48
EGFR P00533 2/20 0.33
KDR P35968 2/20 0.33
FGFR1 P11362 1/20 0.33
CDK1 P06493 1/20 0.33
PIM1 P11309 1/20 0.33
CDK2 P24941 1/20 0.33
MAPKAPK2 P49137 1/20 0.33
GSK3A P49840 1/20 0.33
GSK3B P49841 1/20 0.33
CDK5 Q00535 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eltanexor SCHEMBL16323700 1.00 XPO1 (1.00) XPO1RANBP1KCNH2ESR1HTR1A
Eltanexor SCHEMBL16323699 1.00 XPO1 (1.00) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL26308291 0.95 XPO1 (0.90) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL26312767 0.94 XPO1 (0.88) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL23133144 0.93 XPO1 (0.86) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL16361454 0.93 XPO1 (0.86) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL17788773 0.93 XPO1 (0.86) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL23133415 0.93 XPO1 (0.86) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL17788774 0.93 XPO1 (0.86) XPO1RANBP1KCNH2ESR1HTR1A
SCHEMBL21588154 0.92 XPO1 (0.85) XPO1RANBP1KCNH2ESR1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 380 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075708-A Application of XPO1 inhibitor in preparing medicine for locally treating pruritus 2026-05-26 CN claimed
EP-4727933-A1 COMBINATION THERAPY METHODS FOR TREATING TP53-Y220C MUTANT AND TP53 WILDTYPE LEUKEMIAS Board of Regents, The University of Texas System (US) 2026-04-22 EP claimed
US-20260000697-A1 COMBINATION FORMULATION OF CEDAZURIDINE OTSUKA PHARMA CO LTD (JP) 2026-01-01 US claimed
US-20250161346-A1 METHODS FOR TREATING HEPATITIS B VIRUS INFECTION Shih, Chiaho (US) 2025-05-22 US claimed
WO-2025043187-A1 FIXED DOSE COMBINATIONS OF CEDAZURIDINE AND AZACITIDINE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-02-27 WO claimed
WO-2024263573-A1 COMBINATION THERAPY METHODS FOR TREATING TP53-Y220C MUTANT AND TP53 WILDTYPE LEUKEMIAS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-12-26 WO claimed
CN-119072303-A Combined preparation of sitagliptin 大塚制药株式会社 2024-12-03 CN claimed
US-20240277810-A1 INTERFERONS AND NUCLEAR EXPORT INHIBITORS FOR USE IN METHODS OF TREATING CANCER ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. 2024-08-22 US claimed
CN-118436669-A Pancreatic cancer tumor resisting pharmaceutical composition and application thereof 中山大学孙逸仙纪念医院 2024-08-06 CN claimed
US-20240254564-A1 METHODS FOR PREDICTING AND TREATING CHEMORESISTANCE IN SMALL CELL LUNG CANCER PATIENTS MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-08-01 US claimed
EP-4225281-A1 LMP7-SELECTIVE INHIBITORS FOR THE TREATMENT OF BLOOD DISORDERS AND SOLID TUMORS Merck Patent GmbH (DE) 2023-08-16 EP claimed
CN-116528877-A LMP7 selective inhibitors for the treatment of blood disorders and solid tumors 默克专利股份公司 2023-08-01 CN claimed
WO-2022256371-A1 METHODS FOR PREDICTING AND TREATING CHEMORESISTANCE IN SMALL CELL LUNG CANCER PATIENTS MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2022-12-08 WO claimed
WO-2022256211-A1 INTERFERONS AND NUCLEAR EXPORT INHIBITORS FOR USE IN METHODS OF TREATING CANCER ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) 2022-12-08 WO claimed
US-20220323406-A1 METHODS AND COMPOSITIONS FOR DIFFERENTIATING STEM CELLS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-10-13 US claimed
US-20220249486-A1 SETBP1 AND XPO1 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE AND BETA-THALASSEMIA THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. 2022-08-11 US claimed
US-20220218725-A1 METHODS AND MATERIALS FOR TREATING CANCER MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2022-07-14 US claimed
WO-2022087526-A1 METHODS AND COMPOSITIONS FOR DIFFERENTIATING STEM CELLS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-04-28 WO claimed
WO-2022073994-A1 LMP7-SELECTIVE INHIBITORS FOR THE TREATMENT OF BLOOD DISORDERS AND SOLID TUMORS MERCK PATENT GMBH (DE) 2022-04-14 WO claimed
EP-3968987-A1 METHODS AND MATERIALS FOR TREATING CANCER Mayo Foundation for Medical Education and Research (US) 2022-03-23 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240277810-A1 INTERFERONS AND NUCLEAR EXPORT INHIBITORS FOR USE IN METHODS OF TREATING CANCER XPOT, XPO1, IFNAR1 XPO1 2/4885RANBP1 13/4885KCNH2 4861/4885
US-20220218725-A1 METHODS AND MATERIALS FOR TREATING CANCER DDX21, LMNB1, XPOT XPO1 9/4885RANBP1 499/4885KCNH2 4845/4885
US-20260000697-A1 COMBINATION FORMULATION OF CEDAZURIDINE DCTD, EZH2, DUT XPO1 1108/4885RANBP1 4010/4885KCNH2 4625/4885
US-20220249486-A1 SETBP1 AND XPO1 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE AND BETA-THALASSEMIA XPO1, XPO4, FUBP1 XPO1 1/4885RANBP1 13/4885KCNH2 4622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.