Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | DKK1 | O94907 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 10/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633211 | 0.89 | MAPK10 (0.48) | CDK1CDK2EGFRMAPK10DKK1 | |
| SCHEMBL1633528 | 0.86 | CDK2 (0.46) | MTORSMG1CDK1CDK2EGFR | |
| SCHEMBL13498261 | 0.85 | CDK1 (0.41) | MTORSMG1CDK1CDK2EGFR | |
| SCHEMBL1632981 | 0.83 | CA1 (0.47) | MTORSMG1CDK1CDK2DKK1 | |
| SCHEMBL1632911 | 0.80 | EGFR (0.55) | EGFRMAPK10IKBKBPTK2JAK2 | |
| SCHEMBL1632522 | 0.79 | DKK1 (0.51) | CDK1CDK2MAPK10DKK1GSK3B | |
| SCHEMBL1633652 | 0.79 | NTRK1 (0.43) | CDK1CDK2MAPK10IKBKB | |
| SCHEMBL1633042 | 0.79 | CA2 (0.44) | CDK1CDK2IKBKBPTK2 | |
| SCHEMBL13498354 | 0.78 | MAPK10 (0.49) | CDK1CDK2MAPK10DKK1GSK3B | |
| SCHEMBL1631949 | 0.78 | DKK1 (0.50) | CDK1CDK2MAPK10DKK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |