Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indapamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 1.00 |
| ▸ | CA2 | P00918 | 10/20 | 1.00 |
| ▸ | CA12 | O43570 | 3/20 | 1.00 |
| ▸ | CA3 | P07451 | 3/20 | 1.00 |
| ▸ | CA4 | P22748 | 3/20 | 1.00 |
| ▸ | CA6 | P23280 | 3/20 | 1.00 |
| ▸ | CA5A | P35218 | 3/20 | 1.00 |
| ▸ | CA7 | P43166 | 3/20 | 1.00 |
| ▸ | CA9 | Q16790 | 3/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indapamide SCHEMBL41303 | 1.00 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL29372690 | 1.00 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL476213 | 1.00 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL2329030 | 1.00 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL29377544 | 1.00 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL29496872 | 1.00 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL2989867 | 0.99 | CA1 (0.98) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL3159715 | 0.99 | CA1 (0.98) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL28261247 | 0.96 | CA1 (0.92) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL16180488 | 0.94 | CA1 (0.89) | CA1CA2CA12CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1712 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025050228-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PEPTIDE OR A COMBINATION OF PEPTIDES AGONISTIC TO THE MAS, AT1 AND AT2 RECEPTORS | PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) | 2025-03-13 | — | — | WO | claimed |
| CN-117736324-B | Purification method of anti-Siglec-15 monoclonal antibody | 北京东方百泰生物科技股份有限公司 | 2024-06-28 | — | — | CN | claimed |
| WO-2024134512-A1 | LIPID NANOPARTICLE COMPOSITION | Seqirus Inc. (US) | 2024-06-27 | — | — | WO | claimed |
| US-20240109935-A1 | PROCESS FOR THE PURIFICATION OF MONOCLONAL ANTIBODIES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2024-04-04 | — | — | US | claimed |
| EP-4319816-A1 | ANTI-VENOM ANTIBODIES AND USES THEREOF | Centivax, Inc. (US) | 2024-02-14 | — | — | EP | claimed |
| WO-2024005734-A1 | THE PREPARATION OF ONONIS NATRIX PLANT EXTRACTS AND USE AS A SUPPLEMENT | KASTAMONU ÜNİVERSİTESİ REKTÖRLÜĞÜ (TR) | 2024-01-04 | — | — | WO | claimed |
| EP-4291568-A1 | PROCESS FOR THE PURIFICATION OF MONOCLONAL ANTIBODIES | Council of Scientific & Industrial Research (IN) | 2023-12-20 | — | — | EP | claimed |
| CN-111440226-B | System and method for protein purification | 杭州奕安济世生物药业有限公司 | 2022-06-03 | — | — | CN | claimed |
| WO-2021150574-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | GENENTECH, INC. (US) | 2021-07-29 | — | — | WO | claimed |
| US-20210198741-A1 | IDENTIFICATION OF SPATIAL BIOMARKERS OF HEART DISORDERS AND METHODS OF USING THE SAME | 10X GENOMICS, INC. | 2021-07-01 | — | — | US | claimed |
| WO-1997022714-A1 | DIRECT STAIN SPECIFIC BINDING ASSAYS FOR MICROORGANISMS | QUIDEL CORPORATION (US) | 1997-06-26 | — | — | WO | claimed |
| EP-0574186-B1 | Thin film transistor and active matrix liquid crystal display device | IBM (US) | 1995-05-17 | — | — | EP | claimed |
| EP-0412131-A4 | SUBSTANTIALLY DRY CLEANING WIPE | — | 1992-05-20 | — | — | EP | claimed |
| EP-0412131-A1 | SUBSTANTIALLY DRY CLEANING WIPE. | SHERIDAN CHRISTOPHER H (US) | 1991-02-13 | — | — | EP | claimed |
| WO-1990005771-A1 | SUBSTANTIALLY DRY CLEANING WIPE | SHERIDAN CHRISTOPHER H (US) | 1990-05-31 | — | — | WO | claimed |
| EP-0344144-A2 | Polyglycidamide coating compositions | MONSANTO COMPANY (US) | 1989-11-29 | — | — | EP | claimed |
| EP-0146642-B1 | PROCESS FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXY-2-(4-(FUROYL-2)-PIPERAZIN-1-YL)-QUINAZOLINE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALT | LUDWIG HEUMANN & CO GMBH (DE) | 1988-01-20 | — | — | EP | claimed |
| EP-0156264-A2 | Multi-component cutting element using triangular, rectangular and higher order polyhedral-shaped polycrystalline diamond disks | Eastman Christensen Company (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0020948-A2 | Cask for radioactive material, method of manufacturing such a cask, module used thereby and method of shielding neutrons | THE CARBORUNDUM COMPANY (US) | 1981-01-07 | — | — | EP | claimed |
| EP-0002088-A1 | Tomographic scanner and method | Philips Medical Systems Incorporated (US) | 1979-05-30 | — | — | EP | claimed |