Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indapamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.98 |
| ▸ | CA2 | P00918 | 10/20 | 0.98 |
| ▸ | CA12 | O43570 | 3/20 | 0.98 |
| ▸ | CA3 | P07451 | 3/20 | 0.98 |
| ▸ | CA4 | P22748 | 3/20 | 0.98 |
| ▸ | CA6 | P23280 | 3/20 | 0.98 |
| ▸ | CA5A | P35218 | 3/20 | 0.98 |
| ▸ | CA7 | P43166 | 3/20 | 0.98 |
| ▸ | CA9 | Q16790 | 3/20 | 0.98 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.98 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.98 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.98 |
| ▸ | GAA | P10253 | 1/20 | 0.98 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indapamide SCHEMBL3159715 | 1.00 | CA1 (0.98) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL41303 | 0.99 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL163266 | 0.99 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL2329030 | 0.99 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL29496872 | 0.99 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL29377544 | 0.99 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL29372690 | 0.99 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL476213 | 0.99 | CA1 (1.00) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL28261247 | 0.95 | CA1 (0.92) | CA1CA2CA12CA3CA4 | |
| Indapamide SCHEMBL16180488 | 0.93 | CA1 (0.89) | CA1CA2CA12CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024133427-A1 | DRY POWDER BLEND PHARMACEUTICAL COMPOSITION COMPRISING RAMIPRIL AND INDAPAMIDE | ZAKLADY FARMACEUTYCZNE POLPHARMA S.A. (PL) | 2024-06-27 | — | — | WO | claimed |
| EP-4389118-A1 | DRY POWDER BLEND PHARMACEUTICAL COMPOSITION COMPRISING RAMIPRIL AND INDAPAMIDE | Zaklady Farmaceutyczne Polpharma S.A. (PL) | 2024-06-26 | — | — | EP | claimed |
| EP-1729739-B1 | PROCESS FOR PREPARING A SOLID PHARMACEUTICAL COMPOSITION | SERVIER LAB (FR) | 2016-09-28 | — | — | EP | claimed |
| US-20100172995-A1 | Process For Preparing A Solid Pharmaceutical Composition | LES LABORATOIRES SERVIER (FR) | 2010-07-08 | — | — | US | claimed |
| EP-1713452-B1 | SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION OF INDAPAMIDE | KRKA TOVARNA ZDRAVIL D D NOVO (SI) | 2010-03-24 | — | — | EP | claimed |
| US-20070172524-A1 | Process for preparing a solid pharmaceutical composition | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2007-07-26 | — | — | US | claimed |
| EP-1729739-A1 | PROCESS FOR PREPARING A SOLID PHARMACEUTICAL COMPOSITION | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2006-12-13 | — | — | EP | claimed |
| WO-2005094793-A1 | PROCESS FOR PREPARING A SOLID PHARMACEUTICAL COMPOSITION | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2005-10-13 | — | — | WO | claimed |
| EP-0800384-B1 | PHARMACEUTICAL TABLET FORMULATIONS FOR DIRECT COMPRESSION | ENBALT TRADING LTD (IE) | 2001-03-07 | — | — | EP | claimed |
| EP-1057479-A1 | Pharmaceutical tablet formulations for direct compression | ENBALT TRADING LIMITED (IE) | 2000-12-06 | — | — | EP | claimed |
| EP-0800384-A1 | PHARMACEUTICAL TABLET FORMULATIONS FOR DIRECT COMPRESSION | ENBALT TRADING LIMITED (IE) | 1997-10-15 | — | — | EP | claimed |
| WO-1996018386-A1 | PHARMACEUTICAL TABLET FORMULATIONS FOR DIRECT COMPRESSION | ENBALT TRADING LIMITED (IE) | 1996-06-20 | — | — | WO | claimed |
| WO-2024133427-A1 | DRY POWDER BLEND PHARMACEUTICAL COMPOSITION COMPRISING RAMIPRIL AND INDAPAMIDE | ZAKLADY FARMACEUTYCZNE POLPHARMA S.A. (PL) | 2024-06-27 | — | — | WO | disclosed |
| EP-4389118-A1 | DRY POWDER BLEND PHARMACEUTICAL COMPOSITION COMPRISING RAMIPRIL AND INDAPAMIDE | Zaklady Farmaceutyczne Polpharma S.A. (PL) | 2024-06-26 | — | — | EP | disclosed |
| EP-3340980-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN HMG-COA REDUCTASE INHIBITOR AND AN ECA INHIBITOR | Les Laboratoires Servier (FR) | 2018-07-04 | — | — | EP | disclosed |
| EP-1713452-B1 | SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION OF INDAPAMIDE | KRKA TOVARNA ZDRAVIL D D NOVO (SI) | 2010-03-24 | — | — | EP | disclosed |
| EP-0800384-B1 | PHARMACEUTICAL TABLET FORMULATIONS FOR DIRECT COMPRESSION | ENBALT TRADING LTD (IE) | 2001-03-07 | — | — | EP | disclosed |
| EP-1057479-A1 | Pharmaceutical tablet formulations for direct compression | ENBALT TRADING LIMITED (IE) | 2000-12-06 | — | — | EP | disclosed |
| EP-0800384-A1 | PHARMACEUTICAL TABLET FORMULATIONS FOR DIRECT COMPRESSION | ENBALT TRADING LIMITED (IE) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996018386-A1 | PHARMACEUTICAL TABLET FORMULATIONS FOR DIRECT COMPRESSION | ENBALT TRADING LIMITED (IE) | 1996-06-20 | — | — | WO | disclosed |