Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632510 | 0.91 | IGF1R (0.51) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1633493 | 0.88 | JAK2 (0.58) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1633571 | 0.86 | TBK1 (0.54) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1633304 | 0.83 | CCNT1 (0.45) | CCNT1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL1633537 | 0.82 | SYK (0.50) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1632734 | 0.82 | IGF1R (0.46) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1633643 | 0.81 | CDK4 (0.51) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1632132 | 0.81 | IGF1R (0.46) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1633919 | 0.80 | JAK2 (0.50) | JAK2JAK1TYK2JAK3TBK1 | |
| SCHEMBL1633848 | 0.80 | JAK2 (0.60) | JAK2JAK1TYK2JAK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |