Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331454 | 0.90 | BRAF (0.49) | FLT3MEN1KMT2AIGF1RPLK1 | |
| SCHEMBL16331787 | 0.87 | MAPK9 (0.51) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL16332695 | 0.87 | MAPT (0.42) | ALDH1A1MAPTKDM4EPLK1ABCG2 | |
| SCHEMBL16332328 | 0.85 | MEN1 (0.51) | ALDH1A1MAPTMEN1KMT2AIGF1R | |
| SCHEMBL16332856 | 0.82 | PDGFRB (0.50) | FLT3ALDH1A1IGF1RPLK1PDGFRB | |
| SCHEMBL16332011 | 0.82 | MAPT (0.43) | FLT3ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16332572 | 0.81 | PIK3CA (0.48) | MAPTMEN1KMT2APLK1ABCG2 | |
| SCHEMBL16331745 | 0.81 | BRAF (0.42) | MEN1KMT2AIGF1RKDRAURKA | |
| SCHEMBL16331252 | 0.80 | JAK3 (0.46) | FLT3ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16332095 | 0.80 | RAD52 (0.40) | KMT2AFYNMAPK9MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |