Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.48 |
| ▸ | MTOR | P42345 | 13/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332763 | 0.87 | EGFR (0.43) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16332602 | 0.85 | GABRG2 (0.52) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16332832 | 0.85 | PIK3CA (0.48) | PIK3CAMTORPRKDCTP53MAPT | |
| SCHEMBL16331924 | 0.85 | KDM1A (0.45) | PIK3CAMTORABCG2MEN1KMT2A | |
| SCHEMBL16332328 | 0.85 | MEN1 (0.51) | PIK3CAPRKDCTP53MAPTABCG2 | |
| SCHEMBL16331795 | 0.85 | BRAF (0.43) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16332095 | 0.83 | RAD52 (0.40) | PIK3CAPRKDCRAD52KMT2A | |
| SCHEMBL16331650 | 0.82 | PIK3CA (0.44) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16333060 | 0.82 | PIK3CA (0.50) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16331602 | 0.81 | FLT3 (0.44) | TP53MAPTABCG2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |