Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332219 | 0.87 | FGFR1 (0.49) | PDGFRBPDGFRANPC1RAB9ABRAF | |
| SCHEMBL16332523 | 0.84 | SMN1; SMN2 (0.54) | PDGFRBPDGFRANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16331671 | 0.82 | RAB9A (0.53) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL16331602 | 0.82 | FLT3 (0.44) | PDGFRBPDGFRANPC1RAB9ASHMT2 | |
| SCHEMBL16331647 | 0.81 | FGFR1 (0.48) | PDGFRBPDGFRANPC1RAB9ABRAF | |
| SCHEMBL16333060 | 0.81 | PIK3CA (0.50) | PLK1ABCG2KDRPIK3CAPRKDC | |
| SCHEMBL16332041 | 0.79 | PDE10A (0.44) | PDGFRBPDGFRACSNK2A1BRAFFYN | |
| SCHEMBL16332345 | 0.79 | RAB9A (0.46) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16332845 | 0.79 | PIK3CA (0.51) | NPC1RAB9AFYNPIK3CAPRKDC | |
| SCHEMBL16332134 | 0.78 | SMN1; SMN2 (0.52) | PDGFRBPDGFRANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |