Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 4/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332767 | 0.85 | MAPK9 (0.45) | PIK3CAPRKDCFYN | |
| SCHEMBL16331838 | 0.83 | NTRK1 (0.41) | FYN | |
| SCHEMBL16332799 | 0.81 | KDM1A (0.37) | FYNABCG2 | |
| SCHEMBL16331298 | 0.81 | PIK3CA (0.44) | PIK3CAPRKDCFYNABCG2PIK3CG | |
| SCHEMBL16331865 | 0.80 | BRAF (0.51) | — | |
| SCHEMBL16331614 | 0.79 | GABRG2 (0.49) | PIK3CAPRKDCABCG2PIK3CDPIK3CB | |
| SCHEMBL16331980 | 0.79 | PIK3CA (0.46) | PIK3CAPRKDC | |
| SCHEMBL16332768 | 0.75 | FYN (0.43) | PIK3CAPRKDCFYN | |
| SCHEMBL16332000 | 0.74 | BRAF (0.53) | ABCG2 | |
| SCHEMBL16331787 | 0.74 | MAPK9 (0.51) | PIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |