Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331723 | 0.89 | BRAF (0.43) | EGFRKDRSMN1; SMN2CYP2C9CYP1A2 | |
| SCHEMBL16332551 | 0.89 | SMN1; SMN2 (0.43) | EGFRKDRSMN1; SMN2CYP2C9CYP1A2 | |
| SCHEMBL16331960 | 0.89 | CSF1R (0.46) | SMN1; SMN2CYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16332134 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16331531 | 0.85 | CSF1R (0.47) | KIF11SMN1; SMN2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL16332121 | 0.85 | EGFR (0.44) | EGFRKDRSMN1; SMN2CYP2C9CYP1A2 | |
| SCHEMBL16332223 | 0.84 | SMN1; SMN2 (0.44) | EGFRSMN1; SMN2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL16331697 | 0.84 | RAB9A (0.47) | EGFRKDRSMN1; SMN2CYP2C9CYP1A2 | |
| SCHEMBL16332395 | 0.82 | LMNA (0.47) | EGFRSMN1; SMN2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL16332494 | 0.82 | LMNA (0.47) | EGFRSMN1; SMN2CYP2C9CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |