Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 10/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16333224 | 0.83 | GABRA5 (0.57) | GABRA5GAATSHRNPC1GPBAR1 | |
| SCHEMBL107805 | 0.83 | GABRA5 (0.53) | GABRA5GAATSHRNPC1ALDH1A1 | |
| SCHEMBL27848512 | 0.80 | GABRA5 (0.62) | GABRA5 | |
| SCHEMBL457706 | 0.79 | GPBAR1 (0.59) | GABRA5GAATSHRMEN1KMT2A | |
| SCHEMBL535861 | 0.78 | GABRA5 (0.43) | GABRA5MEN1KMT2A | |
| SCHEMBL535860 | 0.78 | GABRA5 (0.43) | GABRA5MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3981907 | 0.78 | GPBAR1 (0.57) | GABRA5GAATSHRMEN1KMT2A | |
| SCHEMBL27848511 | 0.77 | GABRA5 (0.51) | GABRA5NPC1GPBAR1 | |
| SCHEMBL30684510 | 0.77 | GABRA5 (0.54) | GABRA5GAATSHRMEN1KMT2A | |
| SCHEMBL12543755 | 0.77 | GABRA5 (0.54) | GABRA5GAATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229383-B1 | ISOXAZOLO-PYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-01-18 | — | — | EP | disclosed |
| EP-2227467-B1 | ISOXAZOLO-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-12-31 | — | — | EP | disclosed |