SCHEMBL27848512

SCHEMBL27848512

Cc1onc(-c2ccc(F)cn2)c1CC(=O)O

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GABRA5 P31644 18/20 0.62
AGBL2 Q5U5Z8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL109043 0.83 GABRA5 (0.58) GABRA5
SCHEMBL285552 0.81 GABRA5 (0.55) GABRA5
SCHEMBL16333264 0.80 GABRA5 (0.57) GABRA5
SCHEMBL2673196 0.78 GABRA5 (0.73) GABRA5
SCHEMBL286101 0.77 GABRA5 (0.55) GABRA5
SCHEMBL2928293 0.77 GABRA5 (1.00) GABRA5
SCHEMBL288233 0.77 GABRA5 (0.66) GABRA5
SCHEMBL2926076 0.77 GABRA5 (0.74) GABRA5
SCHEMBL1776581 0.77 GABRA5 (0.73) GABRA5
SCHEMBL286230 0.76 GABRA5 (0.53) GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102414205-A Isoxazole-pyrazole derivatives HOFFMANN LA ROCHE 2012-04-11 CN disclosed