Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | PKLR | P30613 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CPT1A | P50416 | 4/20 | 0.47 |
| ▸ | CPT2 | P23786 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561797 | 0.87 | NR1H3 (0.56) | NPC1NR1H3CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL24286266 | 0.83 | PKM (0.57) | NPC1NR1H3CYP2C9CYP2C19PKM | |
| SCHEMBL18581858 | 0.80 | CPT1A (0.62) | NPC1NR1H3CYP2C9MEN1ALDH1A1 | |
| SCHEMBL1636619 | 0.80 | PKM (0.58) | CYP2C9PKMMEN1ALDH1A1KMT2A | |
| SCHEMBL18581708 | 0.77 | CYP2C9 (0.82) | NPC1NR1H3CYP2C9HTR6CPT1A | |
| SCHEMBL31750691 | 0.75 | CYP2C9 (0.71) | NPC1CYP2C9CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL34475705 | 0.75 | CYP2C9 (0.71) | NPC1CYP2C9CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL21630359 | 0.75 | RIPK2 (0.48) | NPC1CYP2C9CYP3A4PKMPKLR | |
| SCHEMBL24499467 | 0.74 | NPC1 (0.55) | NPC1NR1H3CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL28156631 | 0.74 | RORC (0.66) | NPC1NR1H3PKMMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247595-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-7932254-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2247595-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106445-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |
| US-20090215724-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215724-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, JAK1 | NPC1 4792/4885NR1H3 4656/4885CYP2C9 3169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.