Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.75 |
| ▸ | NPC1 | O15118 | 3/20 | 0.75 |
| ▸ | RAB9A | P51151 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16335756 | 0.93 | CYP3A4 (0.75) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| SCHEMBL16389392 | 0.90 | CYP3A4 (0.75) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| SCHEMBL30288208 | 0.89 | CYP3A4 (0.81) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| SCHEMBL28788159 | 0.88 | KDM4E (0.83) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| SCHEMBL27757185 | 0.88 | CYP3A4 (0.70) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| SCHEMBL16389295 | 0.86 | RAB9A (0.55) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| Biochanin A, Dimethyl Ether SCHEMBL5795557 | 0.86 | CYP3A4 (1.00) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| SCHEMBL18324965 | 0.85 | KDM4E (0.62) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| Pratensein SCHEMBL29349666 | 0.84 | RAB9A (0.73) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 | |
| Pratensein SCHEMBL73557 | 0.84 | RAB9A (0.73) | KDM4ECYP3A4ALDH1A1HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013331-B1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND THEIR USE FOR THE TREATMENT OF CERTAIN HEDGEHOG (HH)-DEPENDENT TUMORS | UNIV DEGLI STUDI DI SIENA (IT) | 2023-03-01 | — | — | EP | disclosed |
| US-10093642-B2 | Multitarget hedgehog pathway inhibitors and uses thereof | Università degli Studi di Roma “La Sapienza” (IT) | 2018-10-09 | — | — | US | disclosed |
| US-20160368886-A1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2016-12-22 | — | — | US | disclosed |
| US-20160368886-A1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2016-12-22 | — | — | US | disclosed |
| EP-3013331-A1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF | Università degli Studi di Siena (IT) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014207069-A1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368886-A1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF | SHH, GLI1, SMO | KDM4E 942/4885CYP3A4 4845/4885ALDH1A1 2823/4885 |
| US-10093642-B2 | Multitarget hedgehog pathway inhibitors and uses thereof | SHH, GLI1, SMO | KDM4E 942/4885CYP3A4 4845/4885ALDH1A1 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.