Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16340660 | 0.86 | DRD2 (0.56) | SIGMAR1ACKR3DRD4DRD2DRD3 | |
| SCHEMBL16340547 | 0.80 | SMPD1 (0.48) | SIGMAR1BCHEACHESMPD1 | |
| SCHEMBL16373183 | 0.80 | HSD17B10 (0.59) | SIGMAR1BCHEACHESMPD1 | |
| SCHEMBL30380101 | 0.76 | SIGMAR1 (0.61) | SIGMAR1DRD2ALDH1A1 | |
| SCHEMBL16373187 | 0.76 | DRD2 (0.44) | SIGMAR1DRD4DRD2ALDH1A1BCHE | |
| SCHEMBL10724020 | 0.73 | MAPT (0.75) | DRD2DRD3ALDH1A1MAPT | |
| SCHEMBL4730287 | 0.72 | TMEM97 (0.68) | SIGMAR1ACKR3 | |
| SCHEMBL31687472 | 0.72 | SIGMAR1 (0.61) | SIGMAR1ACKR3ALDH1A1BCHEACHE | |
| SCHEMBL17372597 | 0.72 | SIGMAR1 (1.00) | SIGMAR1ACKR3 | |
| SCHEMBL16373188 | 0.72 | SMPD1 (0.47) | SIGMAR1BCHEACHESMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013824-A1 | CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Alzprotect (FR) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014207240-A1 | CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ALZPROTECT (FR) | 2014-12-31 | — | — | WO | disclosed |