Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633733 | 0.91 | MEN1 (0.51) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL23314866 | 0.91 | MEN1 (0.51) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL1633739 | 0.84 | KMT2A (0.52) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL1631832 | 0.83 | SIGMAR1 (0.47) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL27311478 | 0.82 | MEN1 (0.51) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL27311505 | 0.82 | ALDH1A1 (0.48) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL883054 | 0.82 | MEN1 (0.48) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL25521297 | 0.80 | MEN1 (0.49) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL11992499 | 0.80 | MEN1 (0.49) | KMT2AALDH1A1MEN1TSHRSIGMAR1 | |
| SCHEMBL7347580 | 0.80 | KMT2A (0.46) | KMT2AALDH1A1MEN1TSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932270-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2011-04-26 | — | — | US | claimed |