Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 16/20 | 0.52 |
| ▸ | JAK2 | O60674 | 9/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12725013 | 0.92 | LRRK2 (0.46) | TBK1JAK2LRRK2 | |
| SCHEMBL1634987 | 0.88 | MAPK10 (0.50) | JAK2LRRK2 | |
| SCHEMBL1633627 | 0.88 | LRRK2 (0.49) | JAK2LRRK2 | |
| SCHEMBL1633826 | 0.87 | TBK1 (0.62) | TBK1JAK2LRRK2IKBKE | |
| SCHEMBL1636472 | 0.84 | LRRK2 (0.49) | JAK2LRRK2 | |
| SCHEMBL1633941 | 0.83 | LRRK2 (0.43) | JAK2LRRK2 | |
| SCHEMBL1632738 | 0.81 | JAK2 (0.59) | JAK2LRRK2 | |
| SCHEMBL1633593 | 0.80 | MAPK10 (0.46) | TBK1JAK2LRRK2 | |
| SCHEMBL1633664 | 0.79 | TBK1 (0.52) | TBK1JAK2LRRK2 | |
| SCHEMBL1633134 | 0.78 | BTK (0.52) | JAK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |