Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633627 | 0.90 | LRRK2 (0.49) | MAPK10LRRK2JAK2CCNT1CDK1 | |
| SCHEMBL1633770 | 0.88 | TBK1 (0.52) | LRRK2JAK2 | |
| SCHEMBL12725013 | 0.88 | LRRK2 (0.46) | MAPK10LRRK2JAK2CCNT1CDK1 | |
| SCHEMBL1633015 | 0.87 | CDK4 (0.51) | MAPK10LRRK2JAK2CDK1CDK4 | |
| SCHEMBL1636472 | 0.86 | LRRK2 (0.49) | MAPK10LRRK2JAK2CCNT1CDK1 | |
| SCHEMBL1633497 | 0.85 | MAPK10 (0.50) | MAPK10LRRK2JAK2CDK4CCNA2 | |
| SCHEMBL1633941 | 0.85 | LRRK2 (0.43) | MAPK10LRRK2JAK2CCNT1CDK1 | |
| SCHEMBL13498322 | 0.84 | LRRK2 (0.51) | MAPK10LRRK2JAK2 | |
| SCHEMBL1632738 | 0.84 | JAK2 (0.59) | MAPK10LRRK2JAK2CCNT1CDK1 | |
| SCHEMBL1633593 | 0.82 | MAPK10 (0.46) | MAPK10LRRK2JAK2CCNT1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |