Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 7/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 6/20 | 0.46 |
| ▸ | CCND1 | P24385 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632409 | 0.92 | JUN (0.49) | JUNMAPK8MAPK10SYKJAK2 | |
| SCHEMBL13362923 | 0.90 | SYK (0.48) | JUNMAPK8MAPK10SYKJAK2 | |
| SCHEMBL1632436 | 0.89 | CDK4 (0.47) | JUNMAPK8MAPK10JAK2TBK1 | |
| SCHEMBL1571308 | 0.87 | SYK (0.46) | JUNMAPK8MAPK10SYKJAK2 | |
| SCHEMBL13498238 | 0.85 | LRRK2 (0.51) | JUNMAPK8MAPK10SYKJAK2 | |
| SCHEMBL1633436 | 0.84 | MAPK10 (0.50) | JUNMAPK8MAPK10SYKJAK2 | |
| SCHEMBL13498239 | 0.83 | CDK4 (0.51) | SYKJAK2TBK1LRRK2CDK4 | |
| SCHEMBL13498240 | 0.83 | CDK4 (0.53) | SYKJAK2TBK1LRRK2CDK4 | |
| SCHEMBL12725100 | 0.83 | CDK4 (0.52) | SYKJAK2TBK1LRRK2CDK4 | |
| SCHEMBL1635198 | 0.82 | TBK1 (0.56) | SYKJAK2TBK1LRRK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |