Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 8/20 | 0.45 |
| ▸ | CDK4 | P11802 | 5/20 | 0.45 |
| ▸ | CCND1 | P24385 | 5/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 5/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724714 | 0.88 | JAK2 (0.56) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL1633548 | 0.80 | JAK2 (0.51) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL8899654 | 0.79 | NPY5R (0.56) | — | |
| SCHEMBL2979457 | 0.78 | CDK9 (0.60) | CDK2PTK2CDK9CCNT1 | |
| Hydrochloric Acid SCHEMBL8890045 | 0.78 | NPY5R (0.55) | — | |
| SCHEMBL1632399 | 0.74 | JAK2 (0.65) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL13313218 | 0.73 | JAK2 (0.59) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL1633821 | 0.72 | STK4 (0.52) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL3005881 | 0.72 | CDK9 (0.68) | JAK2CDK2CDK4CCND1CCNE1 | |
| SCHEMBL1631342 | 0.71 | CDK2 (0.45) | JAK2JAK1TYK2JAK3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |