Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 18/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.60 |
| ▸ | MST1R | Q04912 | 1/20 | 0.60 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3005881 | 0.91 | CDK9 (0.68) | CDK9AURKAMAP4K4ABL1LCK | |
| SCHEMBL2985710 | 0.88 | CDK9 (0.61) | CDK9AURKAMAP4K4ABL1LCK | |
| SCHEMBL14874685 | 0.82 | CDK9 (0.68) | CDK9AURKAMAP4K4ABL1LCK | |
| SCHEMBL3758459 | 0.82 | IKBKB (0.62) | ABL1MAPK8GSK3B | |
| SCHEMBL2995165 | 0.81 | CDK9 (0.66) | CDK9AURKAMAP4K4ABL1LCK | |
| SCHEMBL3005997 | 0.79 | CDK9 (0.70) | CDK9AURKAMAP4K4ABL1LCK | |
| SCHEMBL3008795 | 0.79 | CDK9 (0.63) | CDK9AURKAMAP4K4ABL1LCK | |
| SCHEMBL1633860 | 0.78 | JAK2 (0.55) | CDK9CCNT1CDK2PTK2 | |
| SCHEMBL3013163 | 0.78 | CDK9 (0.67) | CDK9AURKAMAP4K4ABL1LCK | |
| SCHEMBL4107381 | 0.77 | CDK9 (0.55) | CDK9AURKAMAP4K4ABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150011576-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2015-01-08 | — | — | US | claimed |
| US-8841315-B2 | Inhibitors of protein kinases | ASTRAZENECA AB (SE) | 2014-09-23 | — | — | US | claimed |
| US-20130331407-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2013-12-12 | — | — | US | claimed |
| US-8507511-B2 | Inhibitors of protein kinases | INGENIUM PHARMACEUTICALS GMBH (DE) | 2013-08-13 | — | — | US | claimed |
| EP-2137165-B1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2013-04-24 | — | — | EP | claimed |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | claimed |
| EP-2137165-A1 | INHIBITORS OF PROTEIN KINASES | Ingenium Pharmaceuticals GmbH (DE) | 2009-12-30 | — | — | EP | claimed |
| WO-2008129071-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | claimed |
| US-20150011576-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2015-01-08 | — | — | US | disclosed |
| US-20150011576-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2015-01-08 | — | — | US | disclosed |
| US-8841315-B2 | Inhibitors of protein kinases | ASTRAZENECA AB (SE) | 2014-09-23 | — | — | US | disclosed |
| US-8841315-B2 | Inhibitors of protein kinases | ASTRAZENECA AB (SE) | 2014-09-23 | — | — | US | disclosed |
| US-20130331407-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2013-12-12 | — | — | US | disclosed |
| US-8507511-B2 | Inhibitors of protein kinases | INGENIUM PHARMACEUTICALS GMBH (DE) | 2013-08-13 | — | — | US | disclosed |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| EP-2137165-A1 | INHIBITORS OF PROTEIN KINASES | Ingenium Pharmaceuticals GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008129071-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008129071-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130331407-A1 | INHIBITORS OF PROTEIN KINASES | CDK1, CDK2, CDK5 | CDK9 11/4885AURKA 261/4885MAP4K4 88/4885 |
| US-20150011576-A1 | Inhibitors of Protein Kinases | CDK1, CDK2, CDK5 | CDK9 11/4885AURKA 261/4885MAP4K4 88/4885 |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | CDK1, CDK2, CCNI | CDK9 11/4885AURKA 222/4885MAP4K4 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.