Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | REN | P00797 | 8/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16339452 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3KCNH2REN | |
| SCHEMBL22906857 | 0.91 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2REN | |
| SCHEMBL23267243 | 0.91 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2REN | |
| SCHEMBL25308033 | 0.89 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3KCNH2REN | |
| SCHEMBL25304570 | 0.86 | TSHR (0.47) | SLC6A2SLC6A4SLC6A3RENHTR2C | |
| SCHEMBL943620 | 0.84 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KCNH2HTR2C | |
| SCHEMBL2978516 | 0.84 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KCNH2HTR2C | |
| SCHEMBL110365 | 0.84 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KCNH2HTR2C | |
| Hydrochloric Acid SCHEMBL2173176 | 0.83 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KCNH2HTR2C | |
| Bromide SCHEMBL2177195 | 0.83 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KCNH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013812-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | Nektar Therapeutics (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014210436-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS (US) | 2014-12-31 | — | — | WO | disclosed |