Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.61 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16339247 | 0.81 | NOTUM (1.00) | NPSR1RXFP1NOTUMKMT2ASMN1; SMN2 | |
| SCHEMBL16339840 | 0.81 | NOTUM (1.00) | NPSR1RXFP1NOTUMKMT2ASMN1; SMN2 | |
| SCHEMBL16333306 | 0.77 | NOTUM (1.00) | NPSR1RXFP1NOTUMKMT2ASMN1; SMN2 | |
| SCHEMBL439342 | 0.76 | NOTUM (1.00) | NOTUMALDH1A1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL16339371 | 0.76 | L3MBTL1 (0.66) | NPSR1RXFP1NOTUMKMT2ASMN1; SMN2 | |
| SCHEMBL16333328 | 0.76 | NOTUM (1.00) | NPSR1RXFP1TSHRNOTUMKMT2A | |
| SCHEMBL16339846 | 0.76 | NOTUM (0.81) | NPSR1RXFP1NOTUMKMT2ASMN1; SMN2 | |
| SCHEMBL16339818 | 0.75 | NOTUM (1.00) | TSHRNOTUMKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL452479 | 0.74 | NOTUM (0.69) | NPSR1RXFP1NOTUMKMT2ASMN1; SMN2 | |
| SCHEMBL16338969 | 0.74 | NOTUM (0.69) | NPSR1RXFP1NOTUMKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |