Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5078982 | 0.74 | L3MBTL1 (0.57) | L3MBTL1ROCK2LMNAPOLBKMT2A | |
| SCHEMBL24334784 | 0.74 | MAPK14 (0.58) | L3MBTL1ROCK2MAPTCYP3A4MAPK14 | |
| SCHEMBL24334785 | 0.73 | PTGER4 (0.72) | L3MBTL1ROCK2LMNACYP3A4MAPK14 | |
| SCHEMBL1569192 | 0.73 | L3MBTL1 (1.00) | L3MBTL1ROCK2LMNACYP3A4MAPK14 | |
| SCHEMBL15686647 | 0.71 | HPGD (0.81) | L3MBTL1LMNAMAPTPOLBKMT2A | |
| SCHEMBL15246138 | 0.71 | NAMPT (0.74) | ROCK2NAMPT | |
| SCHEMBL2735040 | 0.71 | KMT2A (0.87) | L3MBTL1LMNAMAPTPOLBKMT2A | |
| SCHEMBL12697371 | 0.71 | KMT2A (0.66) | L3MBTL1LMNAMAPTKMT2ACYP1A2 | |
| SCHEMBL5093565 | 0.70 | HDAC3 (0.64) | L3MBTL1ROCK2MAPTPOLBCYP3A4 | |
| SCHEMBL15839871 | 0.70 | KDM4C (0.56) | L3MBTL1MAPTKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014205593-A1 | SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2014-12-31 | — | — | WO | disclosed |