Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 7/20 | 0.67 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15067682 | 0.96 | HSPB1 (0.72) | HSPB1EPAS1MAPTTDP1L3MBTL1 | |
| SCHEMBL29533051 | 0.96 | HSPB1 (0.72) | HSPB1EPAS1MAPTTDP1L3MBTL1 | |
| SCHEMBL20154998 | 0.85 | HSPB1 (0.53) | HSPB1EPAS1MAPTTDP1L3MBTL1 | |
| SCHEMBL29845685 | 0.85 | HSPB1 (0.53) | HSPB1EPAS1MAPTTDP1L3MBTL1 | |
| SCHEMBL29683621 | 0.82 | HSPB1 (0.49) | HSPB1MAPTTDP1L3MBTL1HTT | |
| SCHEMBL16339880 | 0.82 | HSPB1 (0.62) | HSPB1EPAS1MAPTTDP1L3MBTL1 | |
| SCHEMBL431642 | 0.81 | ALDH1A1 (0.62) | HSPB1MAPTTDP1ALDH1A1HIF1A | |
| SCHEMBL29669906 | 0.81 | ALDH1A1 (0.62) | HSPB1MAPTTDP1ALDH1A1HIF1A | |
| SCHEMBL21904820 | 0.80 | HSPB1 (0.71) | HSPB1MAPTTDP1L3MBTL1HTT | |
| SCHEMBL31395357 | 0.80 | HSPB1 (0.71) | HSPB1MAPTTDP1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013828-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014206150-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2014-12-31 | — | — | WO | disclosed |