Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.66 |
| ▸ | NPC1 | O15118 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | STAT1 | P42224 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.63 |
| ▸ | RELA | Q04206 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | PHGDH | O43175 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821419 | 0.92 | RAB9A (0.71) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL12601860 | 0.89 | RAB9A (0.67) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL21517172 | 0.85 | MAPT (0.61) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL1747328 | 0.83 | RAB9A (0.81) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL1914539 | 0.81 | ALDH1A1 (0.60) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10475630 | 0.81 | MAPT (0.91) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL1821250 | 0.80 | MAPT (0.63) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL10352100 | 0.80 | MAPT (0.67) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL1747419 | 0.80 | MEN1 (0.71) | RAB9ANPC1MAPTALDH1A1STAT1 | |
| SCHEMBL1746613 | 0.79 | MAPT (0.66) | RAB9ANPC1MAPTALDH1A1STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790218-B2 | Small molecule activators of calcium-activated chloride channels and methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-20140378510-A1 | SMALL MOLECULE ACTIVATORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378510-A1 | SMALL MOLECULE ACTIVATORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS AND METHODS OF USE | CLCN2, KCNN1, KCNN2 | RAB9A 275/4885NPC1 2738/4885MAPT 4441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.