Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.31 |
| ▸ | EBP | Q15125 | 1/20 | 0.31 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16340907 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| Hydrochloric Acid SCHEMBL16341206 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| Hydrochloric Acid SCHEMBL16341558 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| Hydrochloric Acid SCHEMBL16341117 | 0.78 | MEN1 (0.32) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL16341561 | 0.77 | MEN1 (0.32) | ALDH1A1MEN1KMT2ATSHRTAS1R3 | |
| SCHEMBL16341207 | 0.77 | MEN1 (0.32) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL16340906 | 0.77 | MEN1 (0.32) | ALDH1A1MEN1KMT2ATSHRTAS1R3 | |
| Hydrochloric Acid SCHEMBL2800815 | 0.77 | ALDH1A1 (0.32) | ALDH1A1MAPTPOLBHTTSMN1; SMN2 | |
| SCHEMBL16341118 | 0.75 | MEN1 (0.30) | ALDH1A1MEN1KMT2ATSHR | |
| Hydrochloric Acid SCHEMBL16341135 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2821409-A1 | Metal alkylidene complexes comprising an unsymmetrical unsaturated NHC ligand | Centre National de la Recherche Scientifique (CNRS) (FR) | 2015-01-07 | — | — | EP | claimed |
| EP-2821409-A1 | Metal alkylidene complexes comprising an unsymmetrical unsaturated NHC ligand | Centre National de la Recherche Scientifique (CNRS) (FR) | 2015-01-07 | — | — | EP | disclosed |